Periodicals
Mechanism of essential oil from Schizonepeta tenuifolia in treatment of depression based on network pharmacology and experimental verification
Literature information
- Author：
- QIN Tian-tian1,2 XIE Hong-xiao1,2 HU Jing-wen1,2 ZENG Jiu-seng1,2 LIU Rong1,2 ZENG Nan1,2
- Affiliations：
- State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan province, China 611137;College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan province
- Year：
- 2023
- Keywords：
- essential oil from Schizonepeta tenuifolia; network pharmacology; depression; lipopolysaccharide; mice; mechanism;
- Abstract：
- This paper aimed to explore the antidepressant effect of the essential oil from Schizonepeta tenuifolia Briq. (EOST) on the treatment of depression and its mechanism by using a combination of network pharmacology and the mouse model of lipopolysaccharide (LPS)-induced depression. The chemical components in EOST were identified using gas chromatography-mass spectrometer (GC-MS), and 12 active components were selected as the study objects. The targets related to EOST were obtained by Traditional Chinese Medicines Systems Pharmacology (TCMSP) and SwissTargetPrediction database. The targets related to depression were screened out through GeneCards, Therapeutic Target Database (TTD), and Online Mendelian Inheritance in Man (OMIM) database. The Venny 2.1 was applied to screen out the common targets of EOST and depression. The targets were imported into Cytoscape 3.7.2 to generate “drug?active component?diseasee?target” network diagram. The protein-protein interaction (PPI) network was constructed using STRI