Periodicals
Method of quality marker research and quality evaluation of Chinese materia medica based on drug properties and effect characteristics
Literature information
- Author：
- ZHANG Tie-jun1 WANG Jie2 CHENG Chang-qing1 XU Jun1 GONG Su-xiao1 HAN Yan-qi1 ZHANG Hong-bing1 LIU Chang-xiao3
- Affiliations：
- Tianjin Institute of Pharmaceutical Research, Tianjin, China 300193;Tianjin Institute for Drug Control, Tianjin, China 300070;Center for New Drug Evaluation and Research, State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Insti
- Year：
- 2017
- Keywords：
- quality of Chinese materia medica; quality marker; Chinese medicine industry; drug property; biosynthetic approach; research idea; research method; research approach;
- Abstract：
- The quality of Chinese materia medica (CMM) is the lifeline of Chinese medicine industry. However, many problems are still found in the quality study on CMM, which restricts the healthy development of Chinese medicine industry to a certain extent. Aiming at the problems existing in the quality research on CMM, the research idea, method and approach of quality marker research and quality evaluation of CMM were put forward based on systematic analysis and discussion on the basic properties and clinical features of CMM according to the core concept of quality marker and the combination of research practice, from the perspective of transmission and traceability of quality elements, the relationship between chemical composition and traditional efficacy containing “drug property” and “drug function”, composition analysis of endemicity based on pharmacophylogenetic study and biosynthetic approach. Finally, a new integrated mode of CMM quality evaluation and control was established.